Microfluidic In Vitro Platform for (Nano)Safety and (Nano)Drug Efficiency Screening

Microfluidic technology is a valuable tool for realizing more in vitro models capturing cellular and organ level responses rapid animal-free risk assessment of new chemicals drugs. cell-based devices allow high-throughput screening flexible automation while lowering costs reagent consumption due to their miniaturization. There growing need faster approaches drug development safety (Registration, Evaluation, Authorisation Restriction Chemical Substances, REACH). The work presented describes microfluidic platform vivo-like cell cultivation. It equipped with wafer-based silicon chip including integrated electrodes microcavity. A proof-of-concept using different relevant shows its suitability label-free cytotoxic effects. miniaturized microscope within each module monitors morphology proliferation. Electrodes the channels noninvasive monitoring barrier integrity followed by Each cultivation can be operated individually or interconnected way. interconnection modules aims at simulation whole-body exposure response contribute replacement animal testing studies compliance 3Rs replace, reduce, refine experiments.